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目的 观察曲尼司特联合缬沙坦治疗难治性IgA肾病的实际效果。方法 选取2008年01月～2013年12月我院收治的难治性IgA肾病患儿60例，按随机数字表法将其分成实验组30例，对照组30例，对照组患者应用缬沙坦治疗，实验组患者联合应用曲尼司特、缬沙坦治疗，比较两组治疗效果。结果 治疗后，实验组血纤维蛋白原水平为（2.79±1.21）g/L，血肌酐为（116.21±10.62）μmol/L，内生肌酐清除率为（90.65±10.65）ml/min，内皮素水平为（118.21±12.32）mg/L，疾病治疗总有效率为93.3%，以上数据均优于对照组（P<0.05）。结论 曲尼司特联合缬沙坦治疗难治性IgA肾病，效果满意，值得临床进一步应用、推广。
Objective To observe the effect of tranilast combined with valsartan in the treatment of refractory IgA nephropathy. Methods Sixty children with refractory IgA nephropathy admitted to our hospital from January 2008 to December 2013 were selected and divided into experimental group (30 cases) and control group (30 cases) by random number table method. Patients in the control group were treated with valsartan Treatment, experimental group patients combined tranilast, valsartan treatment, the two groups were compared. Results After treatment, the level of fibrinogen in the experimental group was (2.79 ± 1.21) g / L, the serum creatinine was (116.21 ± 10.62) μmol / L, the rate of endogenous creatinine clearance was (90.65 ± 10.65) ml / (118.21 ± 12.32) mg / L, the total effective rate of disease treatment was 93.3%, the above data were better than the control group (P <0.05). Conclusion Tranilast combined with valsartan in the treatment of refractory IgA nephropathy, with satisfactory results, it is worth further clinical application, promotion.