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目的探讨噪声暴露对心脏的影响。方法将豚鼠分别置于95和100 dB的白噪声环境中,4 h/d,连续14 d后,测量心电图(ECG),观察光镜和电镜下心肌结构的变化,测定心肌组织丙二醛(MDA)含量和血清乳酸脱氢酶(LDH)活性。结果噪声暴露后,豚鼠ECG变化明显,HR明显加快、P-R间期缩短、P波电压增大、T波电压降低等。100 dB暴露组心肌超微结构损伤较严重,心肌组织MDA含量和血清LDH活性分别为(1.645 8±0.050 0)nmol/(mg.prot)和(3 590.06±905.53)U/L,与正常对照组比较,均明显升高(P<0.01)。95 dB暴露组损伤较轻,MDA含量和LDH活性分别为(1.377 5±0.157 3)nmol/(mg.prot)和(2 651.88±487.99)U/L。结论一定剂量的噪声暴露可引起豚鼠心功能紊乱,心肌的形态结构发生病理性改变。
Objective To investigate the effect of noise exposure on the heart. Methods Guinea pigs were exposed to white noise of 95 and 100 dB respectively for 4 h / d for 14 days. Electrocardiogram (ECG) was measured and the changes of myocardial structure under light and electron microscope were observed. The levels of malondialdehyde MDA content and serum lactate dehydrogenase (LDH) activity. Results After the noise was exposed, the changes of ECG in guinea pigs were obvious. The HR obviously increased, the P-R interval shortened, the P wave voltage increased and the T wave voltage decreased. The myocardial ultrastructure damage was more serious in the 100 dB exposure group, and the myocardial MDA content and serum LDH activity were (1.645 8 ± 0.050 0) nmol / (mg.prot) and (3 590.06 ± 905.53) U / L, respectively. Compared with the normal control Group were significantly higher (P <0.01). The 95 dB exposure group was less damaged, and the MDA content and LDH activity were (1.377 5 ± 0.157 3) nmol / (mg.prot) and (2 651.88 ± 487.99) U / L, respectively. Conclusion A certain dose of noise exposure can cause cardiac dysfunction in guinea pigs and pathological changes of myocardial morphology.