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目前认为宿主的免疫反应引起了病毒性肝炎和某些其他肝病的肝细胞损伤,但其确切的发病机制和特异的靶抗原目前仍不清楚。存在于肝细胞膜表面的病毒抗原可以认为是靶抗原。在不能检出病毒抗原时肝细胞损伤仍持续发展,因而推测某些肝细胞膜表面蛋白可能是免疫反应的靶抗原。为此,许多学者进行了分离肝特异性抗原的研究。但在1970年以前,从人和哺乳动物的肝脏中分离到的器官特异性抗原成分都是细胞内成分。自1972年以来才分离成功肝细胞膜抗原,迄今已发现至少存在二种肝特异的膜抗原,即肝特异性膜脂蛋白(LSP)和肝细胞
Currently, it is thought that the immune response of the host causes hepatocellular damage of viral hepatitis and some other liver diseases, but its exact pathogenesis and specific target antigens are still unclear. Viral antigens present on the surface of hepatocyte membranes can be considered as target antigens. Hepatocyte damage continues to develop when viral antigens can not be detected, suggesting that some hepatocyte membrane proteins may be target antigens in immune responses. To this end, many scholars conducted a study of the isolation of liver-specific antigen. However, before 1970, organ-specific antigen components isolated from human and mammalian livers were all intracellular components. Successful hepatocyte membrane antigens have not been isolated since 1972 and at least two liver-specific membrane antigens have been found so far, namely liver-specific membrane lipoproteins (LSPs) and hepatocytes