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本文旨在确定用氯氮平(clozapine)治疗的病人的癫痫发生率,并讨论其可能的诱发因素.美国1972～1988年共有1418例患者用氯氮平治疗,其中至少有41例在氯氮平治疗期间发生全身性强直-阵挛性癫痫,发生率约2.9%。在服用氯氮平期间,8例发生2次抽搐,4例发生3次.治疗期间的癫痫累积发生率持续增加,在156周(3年)时,癫痫的发生率约为9%.196周(3.8年)时,其累积发生率为10%。41例氯氮平诱发癫痫的患者中,男26例,女15例,平均年龄30.8(19～49)岁.开始使用氯氮平到首发癫痫的间期中位数为
The purpose of this study was to determine the incidence of epilepsy in patients treated with clozapine and to discuss its possible predisposing factors.A total of 1418 patients treated with clozapine in the United States from 1972 to 1988, of which at least 41 were treated with clozapine Systemic tonic - clonic seizures occurred during the treatment period, with a rate of approximately 2.9%. During the course of taking clozapine, eight convulsions occurred in two patients and three in four.The incidence of epileptic seizures continued to increase during treatment, and the incidence of epilepsy was about 9% at 156 weeks (3 years) (3.8 years), the cumulative incidence was 10%. Of the 41 patients with epilepsy induced by clozapine, 26 were males and 15 were females with an average age of 30.8 (19-49 years). Median intercostal use of clozapine to first-onset epilepsy was