目的探讨燃煤砷污染对人体肝脏的早期影响,筛选其敏感生物标志物,为慢性砷中毒肝损害的早期诊断、治疗、动态监测及预后判断提供科学依据。方法以课题组既往动态追踪调查的砷中毒患者为调研对象,根据患者肝损害临床表现及常规肝功能试验结果将患者分为无明显肝损害组、轻度损害 Objective To explore the early effects of coal arsenic pollution on human liver and to screen its sensitive biomarkers to provide a scientific basis for the early diagnosis, treatment, dynamic monitoring and prognosis of chronic arsenic poisoning liver damage. Methods Arsenic poisoning patients, who were traced by the research group in the past, were investigated. According to the clinical manifestations of patients with liver damage and the results of routine liver function tests, the patients were divided into no obvious liver damage group, mild damage