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观察了运动训练对纯合子ａｐｏＥ缺陷鼠脂质代谢的影响，结果表明，游泳１２周（２ｈ × ６ｄ／ｗ）后，正常Ｃ５７Ｂ／６Ｊ鼠ＴＣ、ＬＤＬ和ＴＧ均显著降低，结果分别为ＴＣ（６８．０３±１１．８９ｍｇ／ｄ１，５１．４２±１２．５９ｍｇ／ｄｌ，Ｐ＜０．０５％）、ＬＤＬ（２６．０２±５．７９ｍｇ／ｄｌ，１４．８１±８．６５ｍｇ／ｄｌ，Ｐ＜０．０５）和ＴＧ（７５．５２±１２．３１ｍｇ／ｄｌ，３９．２５±３．７３ｍｆｇ／ｄｌ，Ｐ＜０．０１），ａｐｏＥ缺陷鼠ＴＣ、ＬＤＬ和ＴＧ则显著升高，结果分别为ＴＣ（４５９．６９±１４４．１６ｍｇ／ｄｌ，７６５．３２±１５０．３５ｍｇ／ｄｌ，Ｐ＜０．０１、ＬＤＬ（３５０．６０±１０２．１５ｍｇ／ｄｌ，６８８．８５±１４７ｍｇ／ｄｌ，Ｐ＜０．０１）和ＴＧ（７２．１８±１７．４５ｍｇ／ｄｌ，１３０．６４±２５．９５ｍｇ／ｄｌ，Ｐ＜０．０１）。运动训练后ａｐｏＥ缺陷鼠血浆ＴＣ、ＴＧ和ＬＤＬ水平升高，与 ａｐｏＥ缺陷鼠体内脂质经ａｐｏＥ依赖的受体途径清除障碍有关。提示当ａｐｏＥ基因缺陷时，依靠有氧训练改善血脂状况的效果不佳。
The effects of exercise training on lipid metabolism in homozygous apoE mice were observed. The results showed that the levels of TC, LDL and TG in normal C57B / 6J mice were significantly decreased after swimming for 12 weeks (2h × 6d / w), the results were TC 68.03 ± 11.89 mg / d1, 51.42 ± 12.59 mg / dl, P <0.05%), LDL (26.02 ± 5.79 mg / dl, 14.81 ± 8.65 mg / dl, TC, LDL and TG in apoE-deficient mice were significantly higher than those in control group (P <0.05) and TG (75.52 ± 12.31 mg / dl, 39.25 ± 3.73mfg / dl, P < Were TC (459.69 ± 144.16 mg / dl, 765.32 ± 150.35 mg / dl, P <0.01, LDL (350.60 ± 102.15 mg / dl, 688.85 ± 147 mg / dl, P <0.01) and TG 72.18 ± 17.45mg / dl, 130.64 ± 25.95mg / dl, P <0.01) .After exercise training, plasma TC, TG and LDL levels in apoE-deficient mice increased significantly compared with those in apoE-deficient mice Deletion of obstacles via the apoE-dependent receptor pathway suggests that reliance on aerobic training to improve blood lipids is not effective when the apoE gene is defective.