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国内外研究已证实血浆内皮素(ET)参与脑血管病的病理损害过程,本文采用放射免疫技术,在不同时相观察急性脑血管病患者血浆和脑脊液ET变化规律,并探讨了其临床意义.资料与方法一、研究对象本组共126例,脑梗塞60例,男36例,女24例,年龄64.8±8.3岁,伴高血压24例,伴糖尿病16例;脑出血54例,男34例,女20例,年龄60.5±9.5岁;蛛网膜下腔出血(SAH)12例,男8例,女4例,年龄40.7±10.1岁.均为1994年7月～1996年6月在我院神经内科住院患者,全部病例诊断符合1986年《中华医学会第二次全国脑血管病学术会议第二次修定标准》,除根据临床症状、体征外,均在发病3d内做头颅CT或MRI证实,蛛网膜下腔出血经腰穿证实.脑梗塞和脑出血患者入院时均按改良爱丁堡及斯堪的那维亚评分进行神经功能缺损程度评分,脑梗塞轻型20例,中型31例,重型9例;脑出血轻型18冽,中型27例,重型9例.
Domestic and foreign studies have confirmed that plasma endothelin (ET) is involved in the pathological process of cerebrovascular disease. In this paper, radioimmunoassay was used to observe the changes of plasma and cerebrospinal fluid (ET) in patients with acute cerebrovascular disease at different time phases and its clinical significance was discussed. Materials and Methods A study of 126 patients in this group, 60 cases of cerebral infarction, 36 males and 24 females, aged 64.8 ± 8.3 years, with hypertension in 24 cases, with diabetes in 16 cases; 54 cases of cerebral hemorrhage, male 34 Cases, 20 females, aged 60.5 ± 9.5 years; 12 cases of subarachnoid hemorrhage (SAH), 8 males and 4 females, aged 40.7 ± 10.1 years, all from July 1994 to June 1996 in my Hospital neurology inpatients, all cases diagnosed in line with the 1986 “Chinese Medical Association Second National Cerebrovascular Disease Conference on the second revision of the standard”, in addition to based on clinical symptoms and signs, were made within the first 3d head CT or MRI confirmed that subarachnoid hemorrhage confirmed by lumbar puncture.The patients with cerebral infarction and cerebral hemorrhage were admitted according to modified Edinburgh and Scandinavia scores of neurological deficit score, 20 cases of mild cerebral infarction, 31 cases of medium-sized, 9 cases of heavy; cerebral hemorrhage light 18 冽, medium 27 cases, 9 cases of heavy.