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目的:通过对先天性心脏病(CHD)及CHD伴肺动脉高压(PH)患者血清中肿瘤坏死因子α(TNF-α)水平的检测,进一步明确其与CHD伴PH的关系。方法:采用实验研究策略,利用ELISA方法测定48例CHD患儿,无PH、轻度PH、中度PH、重度PH各12例,四组患者静脉血清中TNF-α的水平变化。结果:TNF-α在重度PH明显高于中度、轻度及无PH(P<0.01),尤以重度与无PH之间(P<0.001)。结论:左向右分流型CHD患儿TNF-α参与CHD PH的形成,可能对CHD PH程度的评估、手术指征及预后起着重要作用。
Objective: To investigate the relationship between serum CHD and PH in patients with congenital heart disease (CHD) and CHD complicated with pulmonary hypertension (PH) by detecting the level of tumor necrosis factor-α (TNF-α) in serum. Methods: The experimental method was used to measure the level of TNF-α in venous serum of 48 CHD children with no PH, mild PH, moderate PH and severe PH by ELISA. Results: TNF-α was significantly higher than moderate, mild and no PH in severe PH (P <0.01), especially between severe and non-PH (P <0.001). CONCLUSIONS: TNF-α is involved in the formation of CHD PH in children with left-to-right shunt CHD and may play an important role in assessing the extent of CHD PH, indications for surgery, and prognosis.