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目的了解类风湿性关节炎(RA)患者关节外表现的发生情况,提高对RA关节外表现的认识。方法对1997年1月～2008年12月间京山县人民医院收治的201例RA患者的临床资料进行回顾性分析。结果11年间共收治RA患者201例,其中活动期181例,缓解期20例。RA伴关节外表现发生率41.79%(84/201),女性患者显著多于男性(P<0.05)。年龄大于50岁者关节外表现发生率高(P<0.01)。发生于活动期者占83.33%(70/84),而发生在缓解期者占16.67%(14/84)。关节外表现中贫血最为多见,其次为肺脏损害,皮肤、心脏损害。侵犯眼部、胃肠道、肾脏及器官淀粉样变的则较少,伴有类风湿因子阳性、活动期、病程较长的患者易合并关节外表现。结论RA患者伴关节外表现者并非少见,女性患者关节外表现发生率多,男性肺脏受累发生率较高,皮肤受累可提示早期类风湿关节炎,关节外表现的发生随RA活动性、疾病严重程度,病变范围的增加有增多的趋势。
Objective To understand the occurrence of extra-articular manifestations in patients with rheumatoid arthritis (RA) and to improve their understanding of the extra-articular manifestations of RA. Methods The clinical data of 201 RA patients admitted to Jingshan County People’s Hospital from January 1997 to December 2008 were retrospectively analyzed. Results A total of 201 RA patients were admitted during the 11 years, of which 181 were active and 20 were remission. The incidence of extra-articular manifestations of RA was 41.79% (84/201), with significantly more women than men (P <0.05). The extra-articular age was higher in those over 50 years of age (P <0.01). Occurred in the active period accounted for 83.33% (70/84), while those in the remission accounted for 16.67% (14/84). The most common manifestations of articular anemia, followed by lung damage, skin, heart damage. Invasion of the eye, gastrointestinal tract, kidneys and organs less amyloidosis, associated with rheumatoid factor positive, active, longer duration of patients prone to merge with the performance of the joints. Conclusion The extra-articular manifestations of RA patients are not uncommon. The incidence of extra-articular manifestations in female patients is high, and the incidence of lung involvement in male patients is higher. The involvement of the skin may indicate early rheumatoid arthritis. The appearance of extra-articular disease is associated with RA activity and serious disease The extent of the lesion increased with the increasing trend.