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目的观察解毒活血配方颗粒冲服对经皮冠状动脉介入术(PCI)患者的围术期心肌损伤的影响。方法 160例接受PCI术的心绞痛患者随机分为解毒活血组(n=84)和对照组(n=76),解毒活血组给予常规治疗同时术前第7天给予解毒活血配方颗粒冲服,每日1剂。对照组给予基础药物治疗。测定PCI术前及术后12 h、24 h的血清肌酸激酶同工酶(CK-MB)和肌钙蛋白I(cTn I)浓度。结果解毒活血组PCI术后12 h、24 h cTn I和CK-MB水平均显著低于对照组(P=0.0038,P=0.027 6;P=0.001 2,P=0.002 7)。解毒活血组患者术后cTn I和CK-MB升高大于正常值3倍者构成比均显著低于对照组(P=0.008 2,P=0.007 6)。结论术前给予解毒活血配方颗粒对于PCI围手术期病人的心肌损伤具有一定的保护作用。
Objective To observe the effect of Jiedu Huoxue formula granule on perioperative myocardial injury in percutaneous coronary intervention (PCI) patients. Methods One hundred and sixty patients with angina pectoris undergoing PCI were randomly divided into Jiedu Huoxue group (n = 84) and control group (n = 76). The patients in Jiedu Huoxue group were given conventional treatment and 7 days before operation. 1 dose. The control group was given basic drug treatment. Serum levels of CK-MB and troponin I (cTn I) were measured before and 12 h and 24 h after PCI. Results The levels of cTn I and CK-MB at 12 h and 24 h after PCI in the Jieduhuoxue group were significantly lower than those in the control group (P = 0.0038, P = 0.027 6; P = 0.001 2, P = 0.002 7). The ratio of cTn I and CK-MB in patients with detoxification and activating blood was significantly higher than that in patients with normal control (P = 0.008 2, P = 0.007 6). Conclusion Preoperative administration of detoxification and blood circulation prescription granule has certain protective effect on myocardial injury in perioperative patients.