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目的 :探讨地佐辛和曲马多治疗七氟烷复合瑞芬太尼维持的小儿全麻术后苏醒期躁动的安全性及有效性。方法:选择瑞芬太尼复合七氟烷小儿全麻术后苏醒期发生中度躁动的患儿90例,随机分为3组,记录患儿给药前,给药后5、10、15分钟的心率、呼吸、镇静、躁动、疼痛评分的变化,记录患儿在PACU停留时间以及不良反应的发生情况。结果:地佐辛组与曲马多组两组患儿在给药后15分钟镇静、躁动、疼痛评分与给药前相比有显著差异(P<0.05);地佐辛组与曲马多组在5分钟、10分钟镇静、躁动、疼痛评分比较差异均有统计学意义(p<0.05)。结论:地佐辛、曲马多治疗七氟烷复合瑞芬太尼小儿全麻苏醒期中度躁动均有效,地佐辛治疗躁动起效快于曲马多,但地佐辛可引起一过性的呼吸抑制。
Objective: To investigate the safety and efficacy of dezocine and tramadol for the recovery of agitation in children after general anesthesia with sevoflurane and remifentanil. Methods: Totally 90 children with moderate agitation after remifentanil combined sevoflurane anesthesia were randomly divided into 3 groups. Before and after the administration, 5,10,15 minutes Heart rate, respiratory, sedation, restlessness, changes in pain score, record the children with PACU residence time and the incidence of adverse reactions. Results: The dezocine group and tramadol group were sedated at 15 minutes after administration, and the restlessness and pain score were significantly different from those before administration (P <0.05). Dezocine group and tramadol Group 5 minutes, 10 minutes sedation, restlessness, pain scores were statistically significant differences (p <0.05). CONCLUSION: Dezocine and tramadol are effective in treating general agitation of anesthesia in sevoflurane combined with remifentanil during awakening. Dezocine is more effective than tramadol in treating agitation, but dezocine can cause transient Respiratory depression.