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上海第二医科大学微生物学教研室李彪如等首次应用鸭乙型肝炎病毒(DHBV)加大肠杆菌内毒素诱导方法,建立了鸭急性肝坏死动物模型。结果发现:先肝内注射大肠杆菌内毒素,24h 后再静脉内激发性注射 DHBV 者,易造成一叶或二叶肝坏死。而第一次肝内注射内毒素,24h 后静脉内注入生理盐水;或二次均注入生理盐水者均未发现肝坏死病理变化。若第一次肝内注入 DHBV,第二次静脉内注入内毒素,病理变化则明显轻于第一组,仅出现轻
Shanghai Second Medical University Department of Microbiology Li Biao Ru first application of duck hepatitis B virus (DHBV) plus E. coli endotoxin induction method, the establishment of a duck model of acute liver necrosis. The results showed that: first intrahepatic injection of E. coli endotoxin, 24h and then intravenous injection of DHBV, can easily lead to one or two lobar liver necrosis. The first intrahepatic injection of endotoxin, 24h after intravenous injection of saline; or secondary injection of normal saline were not found pathological changes of liver necrosis. If the first intrahepatic injection of DHBV, a second intravenous injection of endotoxin, the pathological changes were significantly lighter than the first group, only mild