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目的:探讨检测胸水中血管内皮生长因子(VEGF)、肿瘤坏死因子(TNF-α)水平对良恶性胸水的鉴别诊断意义。方法:采用酶联免疫检测法(ELISA)测定34例良性胸腔积液患者和44例恶性胸腔积液患者胸水中VEGF、TNF-α水平。结果:良性胸腔积液组患者胸水中TNF-α水平显著高于恶性胸腔积液组(P<0.05);良性胸腔积液组患者胸水中VEGF水平显著低于恶性胸腔积液组(P<0.05)。结论:胸水中VEGF、TNF-α水平的检测对良、恶性胸水患者具有鉴别诊断意义。
Objective: To investigate the differential diagnosis of benign and malignant hydrothorax in the detection of pleural effusion of vascular endothelial growth factor (VEGF) and tumor necrosis factor (TNF-α). Methods: The levels of VEGF and TNF-α in pleural effusion of 34 patients with benign pleural effusion and 44 patients with malignant pleural effusion were determined by enzyme linked immunosorbent assay (ELISA). Results: The level of TNF-α in pleural effusion was significantly higher in patients with benign pleural effusion than in malignant pleural effusion (P <0.05). The VEGF level in pleural effusion was significantly lower in patients with benign pleural effusion than in malignant pleural effusion (P <0.05) ). Conclusion: The detection of VEGF and TNF-α in pleural effusion has the significance of differential diagnosis in patients with benign and malignant pleural effusion.