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为了解慢性肾功能衰竭（ＣＲＦ）患者血浆胃动素水平对胆囊运动功能的影响，通过Ｂ超测定了１７例正常人和２２例ＣＲＦ患者口服红霉素前后，胆囊运动功能的变化；并采用放射免疫分析法测定两组空腹血浆胃动素。结果显示：ＣＲＦ组空腹胆囊体积（ＦＧＶｓ）和剩余胆囊体积明显小于正常组（Ｐ均＜０．０１），但两组最大排空率差异无显著性（Ｐ＞０．０５），口服红霉素后正常组ＦＧＶｓ和剩余胆囊体积均明显减少（Ｐ均＜０．０５），但ＣＲＦ组无明显变化。ＣＲＦ组空腹血浆胃动素水平显著高于正常组，直线相关分析表明，其血浆胃动素水平与空腹胆囊体积呈显著负相关。提示高胃动素血症可能是ＣＲＦ患者胆囊运动功能紊乱主要原因之一。
To investigate the influence of plasma motilin level on gallbladder motility in patients with chronic renal failure (CRF), the changes of gallbladder motor function before and after oral administration of erythromycin in 17 normal subjects and 22 CRF patients were determined by B-mode ultrasonography. Two groups of fasting plasma motilin were determined by radioimmunoassay. The results showed that the fasting gallbladder volume (FGVs) and residual gallbladder volume in CRF group were significantly lower than those in normal group (all P <0.01), but there was no significant difference between the two groups (P> 0.05) The volume of FGVs and remaining gallbladder in the normal group were significantly decreased (all P <0.05), but there was no significant change in the CRF group. The level of fasting plasma motilin in CRF group was significantly higher than that in normal group. The linear correlation analysis showed that there was a significant negative correlation between the level of plasma motilin and the volume of fasting gallbladder. Hint hypermontethemia may be one of the main causes of gallbladder dysfunction in patients with CRF.