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目的探讨血清高敏C反应蛋白(hsC-RP)水平与妊娠糖尿病(GDM)的相关性。方法在妊娠中晚期检测孕妇的血清hsC-RP水平。将患GDM的306例孕妇作为病例组(GDM组),糖耐量正常的347名孕妇作为对照组(Con组),比较两组的血清hsC-RP水平,再按hsC-RP水平四分位,将研究对象分为4组,进行Logistic回归分析。结果 GDM组的血清hsC-RP中位数水平明显高于Con组(3.01 mg/Lvs2.15 mg/L,P<0.01)。根据hsC-RP水平四分位的结果,将研究对象分为4组,第1组hsC-RP<1.41 mg/L,第2组hsC-RP 1.41～2.41 mg/L,第3组hsC-RP 2.42～4.60 mg/L,第4组hsCRP≥4.61 mg/L,相应的GDM的检出率分别为36.81%、42.68%、48.47%、59.51%。调整年龄、孕次、孕前BMI、SBP、DBP及糖尿病家族史等因素,行Logistic回归分析发现,hsC-RP是GDM的独立危险因素(OR值为1.27,95%CI为1.08～1.49,P<0.01)。结论 GDM患者妊娠中晚期hsC-RP水平明显升高,慢性炎症可能参与了GDM的发生。
Objective To investigate the correlation between serum hs-CRP levels and gestational diabetes mellitus (GDM). Methods Serum levels of hsC-RP were measured in the second trimester of pregnancy. Three hundred and sixty pregnant women with GDM were enrolled in the study as the case group (GDM group) and 347 pregnant women with normal glucose tolerance (Con group). Serum hsC-RP levels were compared between the two groups, followed by hsC-RP level quartiles, The subjects were divided into four groups, Logistic regression analysis. Results The median serum hsC-RP level in GDM group was significantly higher than that in Con group (3.01 mg / L vs 2.15 mg / L, P <0.01). According to the results of quartiles of hsC-RP, the subjects were divided into 4 groups: hsC-RP <1.41 mg / L in group 1, 1.41-2.41 mg / L in group 2, hsC-RP 2.42 ~ 4.60 mg / L, the fourth group hsCRP≥4.61 mg / L, the corresponding detection rate of GDM were 36.81%, 42.68%, 48.47%, 59.51% respectively. Logistic regression analysis showed that hsC-RP was an independent risk factor for GDM (OR = 1.27, 95% CI: 1.08-1.49, P < 0.01). Conclusions The level of hsC-RP in the second trimester of pregnancy is significantly increased in GDM patients, and chronic inflammation may be involved in the occurrence of GDM.