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探讨急性白血病（ＡＬ）血脂水平和预后的关系。方法检测５６例ＡＬ血清总胆固醇（ＴＣ）、甘油三脂（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）。结果初诊时ＴＣ、ＬＤＬ－Ｃ与白细胞计数及骨髓增生度显著负相关；获缓解的患者诱导化疗后ＴＣ及ＬＤＬ－Ｃ均比化疗前明显上升（Ｐ＜０．０１），而未缓解患者诱导化疗前后上述各项指标均无显著变化（Ｐ＞０．１）。此外，复发后ＴＣ及ＬＤＬ－Ｃ比复发前显著下降（Ｐ＜０．０５）。结论血脂水平是判断ＡＬ预后的有用指标。
To investigate the relationship between serum lipid levels and prognosis in patients with acute leukemia (AL). Methods Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were detected in 56 patients with AL. Results TC and LDL-C were significantly negatively correlated with leukocyte count and myeloproliferation at the time of initial diagnosis; TC and LDL-C after induction chemotherapy were significantly higher than those before chemotherapy (P<0.01). There was no significant change in the above indicators before and after chemotherapy (P>0.1). In addition, TC and LDL-C decreased significantly after recurrence (P<0.05). Conclusions Lipid levels are useful indicators for predicting AL prognosis.