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目的 :探讨血清非甲—非庚肝病患者的病因学。方法 :采用免疫组织化学和原位杂交技术对 10 4例不明原因各型肝炎患者的肝组织进行肝炎病毒抗原和核酸的检测。结果 :病毒抗原和核酸的总检出率为 85 6 % ,其中单纯HBV感染率为 6 73 % ,HCV为 0 96 % ,单纯HGV感染率为 14 42 % ,单纯TTV感染患者占 10 5 8% ,各种重叠感染者占 5 2 88% (5 5 / 10 4) ,仍有 14 42 % (15 / 10 4)病因不明。结论 :血清非甲—非庚肝病患者肝组织中以HBV、HCV或 /和HGV、TTV重叠感染较多 ,仍有部分病因不明
Objective: To investigate the etiology of patients with non-A-non-hepatic cirrhosis. Methods: Immunohistochemistry and in situ hybridization were used to detect hepatitis virus antigens and nucleic acids in 104 liver tissues of patients with hepatitis C of unknown cause. Results: The overall detection rate of viral antigens and nucleic acids was 85.6%. Among them, the simple HBV infection rate was 6 73%, the HCV was 96%, the simple HGV infection rate was 14 42% and the pure TTV infection was 1058% , 5 2 88% (5 5/10 4) were all kinds of overlapping infections and 14 42% (15/10 4) were still unknown. Conclusion: There is more overlap of HBV, HCV or / and HGV and TTV in the serum of patients with non-A-C hepatic disease, and some etiologies are unknown