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作者们报道自1977年3月至1978年11月共治疗晚期头颈鳞癌45例(舌癌9例,鼻咽癌8例,喉癌7例,扁桃体癌6例,口底癌6例,腭癌3例,咽癌2例,龈癌1例,梨状窝癌1例,原发灶未定2例)。其中23例过去未作过任何治疗。治疗前均详细询问病史并作全面体格检查,20项生化检测,胸部正侧位片,肺功能检查,肌酐清除率测定,大多数病人还作电测听检查,有些病人作肝和骨扫描。要求白细胞至少要在4000/mm~3以上,血小板在150,000/mm~3以上。血清肌酐含量<2.0mg/dl,肌酐清除率>50mg/分。如病人年龄超过70,有明显慢性肺部疾患或已接受过博莱霉素100mg/m~2体表面积以上的均不采用本法治疗。
The authors reported that 45 cases of advanced head and neck squamous cell carcinoma were treated from March 1977 to November 1978 (9 cases of tongue cancer, 8 cases of nasopharyngeal carcinoma, 7 cases of laryngeal cancer, 6 cases of tonsillar cancer, and 6 cases of floor cancer, There were 3 cases of carcinoma, 2 cases of pharynx carcinoma, 1 case of orbital carcinoma, 1 case of pyriform sinus carcinoma, and 2 cases of primary lesion undecided). Of these, 23 cases had not been treated in the past. Before treatment, patients were asked detailed history and a full physical examination, 20 biochemical tests, positive lateral chest radiographs, pulmonary function tests, and creatinine clearance tests. Most patients also performed electrical audiometry tests, and some patients had liver and bone scans. It is required that leukocytes should be at least 4000/mm~3 and platelets should be above 150,000/mm~3. Serum creatinine content <2.0mg/dl, creatinine clearance> 50mg/min. If the patient’s age exceeds 70, no significant chronic lung disease or bleomycin 100 mg/m2 body surface area or above will be treated with this method.