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1898年Horsley首次作经颅垂体切除术成功,1906年Schloffer提出经蝶窦垂体切除术。1909年Cushing报告经鼻中隔蝶窦部分垂体切除术一例,情况显著改善;Hirsch(1910)亦采用经鼻中隔蝶窦垂体切除术成功,当时经医学会肯定了此术的优越性,即直接进到蝶鞍,手术损伤小且无疤痕;但可致脑脊液鼻漏继发脑膜炎,有较高的死亡率。嗣后的研究表明,垂体切除术可使肢端肥大症病状消退,但可发生继发性垂体功能不足,概决定于病变组织切除多少和健康组
In 1898 Horsley made his first successful transcranial pituitary resection. In 1906 Schloffer proposed transsphenoidal pituitaryectomy. In 1909, Cushing reported a case of transsphenoidal transsphenoidal sinus pituitary resection. The situation was significantly improved. Hirsch (1910) also used transsphenoidal sphenoidal sinus pituitary resection successfully. At the time, the Medical Society confirmed the superiority of the procedure, ie, directly into the butterfly. Saddle, the surgical injury is small and no scar; but it can cause meningitis secondary to meningitis, and has a higher mortality. Later studies showed that pituitary resection can ameliorate symptoms of acromegalic disease, but secondary hypopituitarism may occur, depending on how much the disease is removed and the healthy group.