目的探讨人脑星形细胞瘤发生、发展及预后的分子生物学基础。方法应用原位分子杂交技术检测了３４例人脑星形细胞瘤组织中ｂｃｌ┐２基因ｍＲＮＡ表达情况。结果ｂｃｌ┐２表达阳性率分别为Ｉ级星形细胞瘤５／８、ＩＩ级星形细胞瘤７／１２、Ⅲ～Ⅳ级星形细胞瘤６／１４。结论ｂｃｌ┐２是人脑星形细胞瘤常见被激活的凋亡抑制基因，对人脑星形细胞瘤的发生、发展及治疗有重要意义 Objective To explore the molecular biology basis of the occurrence, development and prognosis of human astrocytoma. Methods In situ hybridization was used to detect the mRNA expression of bcl┐2 in 34 cases of human brain astrocytoma. Results The positive rates of bcl-2 expression were grade I ascites 5/8, grade II ascites 7/12, grade III-IV astrocytoma 6/14. Conclusion bcl┐2 is a common apoptosis-inhibiting gene activated by human astrocytoma, which is of great importance to the occurrence, development and treatment of human astrocytoma