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目的:观察火麻仁精油胶囊降脂、抗氧化、抗疲劳作用。方法:分别采用大鼠高血脂模型预防给药试验,正常小鼠和溴代苯致小鼠肝脂质过氧化模型试验,小鼠和大鼠游泳试验分别考察火麻仁精油胶囊抗高血脂、肝脂质过氧化、提高体力作用。结果:火麻仁精油胶囊1g/kg可明显降低TC,增高HDL-C/TC;0.5、1g/kg可显著增高溴代苯模型小鼠的肝组织SOD活力降低MDA含量的增高;0.5、1g/kg可显著延长小鼠的游泳时间;1g/kg可显著降低运动后小鼠和大鼠血清乳酸和尿素的含量。结论:火麻仁精油胶囊有一定的降脂、抗肝脂质过氧化作用、抗疲劳作用,可通过保护血管硬化,消除机体受到脂质过氧化物的伤害,以及通过增强机体的有氧代谢改善体力,从而达到抗衰老的目的。
Objective: To observe the lipid-lowering, anti-oxidation and anti-fatigue effects of Hempen essential oil capsules. METHODS: Rat hyperlipidemia model was used to prevent drug administration test, normal mouse and bromobenzene-induced mouse model of hepatic lipid peroxidation, and mouse and rat swimming test were used to examine Hefei Ren oil capsule for anti-hyperlipidemia. Liver lipid peroxidation, improve physical function. Results: 1 g/kg of Hempen essential oil capsules can significantly reduce TC and increase HDL-C/TC; 0.5 and 1 g/kg can significantly increase the SOD activity of liver tissue in mice with bromobenzene and reduce the increase of MDA content; 0.5, 1g /kg can significantly prolong the swimming time of mice; 1g/kg can significantly reduce the content of lactate and urea in mice and rats after exercise. Conclusion: Hempen oil capsules have certain lipid-lowering, anti-hepatic lipid peroxidation and anti-fatigue effects, can protect the vascular sclerosing, eliminate the damage of the body from lipid peroxide, and enhance the body’s aerobic metabolism. Improve physical strength, so as to achieve the purpose of anti-aging.