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目的研究医院内获得性假丝酵母菌感染特点,观察临床分离的假丝酵母菌分布及其耐药性。方法通过对临床标本分离培养和菌种鉴定方法,对医院内获得真菌感染患者的标本进行了检测。结果共分离出126株假丝酵母菌均来自病人血液标本,其中白色假丝酵母菌74株(58.70%),其余分别为光滑假丝酵母菌24株、热带假丝酵母菌13株、近平滑假丝酵母菌12株和其它假丝酵母菌6株。临床分离的假丝酵母菌除对氟康唑耐药率达到58.90%之外,对其他抗真菌药物耐药率较低。结论医院内获得性假丝酵母菌感染主要是白假丝酵母菌,均分离自血液标本,提示需要监测真菌耐药性发展趋势。
Objective To study the characteristics of Candida albicans infection in hospital and to observe the distribution and drug resistance of Candida isolated clinically. Methods The specimens of patients with fungal infection in the hospital were tested by isolation and culture of clinical specimens and identification of strains. Results A total of 126 Candida were isolated from the blood samples of patients, including 74 Candida albicans (58.70%), the rest were 24 Candida glabrata, Candida tropicalis, nearly smooth Candida albicans 12 strains and other Candida 6 strains. Candida clinical isolates except fluconazole resistance rate reached 58.90%, the other antifungal drug resistance rate is low. Conclusion Candida albicans infection in hospital is mainly caused by Candida albicans, which are all isolated from blood samples, suggesting the need of monitoring the development trend of fungal drug resistance.