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目的比较不同药物治疗进展期胃癌患者的临床疗效。方法将50例进展期胃癌患者按1:1比例分成两组,实验组联合卡培他滨、奥沙利铂治疗,对照组联合替吉奥、奥沙利铂治疗,统计两组药物有效率及实验室不良反应发生情况。结果实验组药物有效率略高于对照组,但差异无统计学意义具有可比性(60.0%VS 50%,P>0.05),两组患者均出现不同程度的白细胞减少、血红蛋白减少、血小板减少、肝功能异常、肾功能异常,但组间差异无统计学意义(P>0.05)。结论卡培他滨联合奥沙利铂与替吉奥联合奥沙利铂治疗进展期胃癌,均能取得较佳的临床效果,均存在临床推广价值。
Objective To compare the clinical effects of different drugs in patients with advanced gastric cancer. Methods Fifty patients with advanced gastric cancer were divided into two groups according to the ratio of 1: 1. The experimental group was treated with capecitabine and oxaliplatin, and the control group was treated with tiagnesium and oxaliplatin. The effective rate And laboratory adverse reactions occurred. Results The effective rate of the experimental group was slightly higher than that of the control group, but the difference was not statistically significant (60.0% vs 50%, P> 0.05). There were different degrees of leukopenia, hemoglobin, thrombocytopenia, Hepatic dysfunction and renal dysfunction, but there was no significant difference between groups (P> 0.05). Conclusions Both capecitabine combined with oxaliplatin and tioguanide combined with oxaliplatin can achieve better clinical effect in advanced gastric cancer, and both of them have clinical value of popularization.