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OBJECTIVE To develop and fully validate an HPLC-MS/MS method for the determination of test compound A027P in acidified cynomolgus monkey plasma and the TK sample bioanalysis process.MEHTOD AND RESULTS A simple and sensitive HPLC-MS/MS method was developed and fully validated in CDSER to determine A027P concentration in cynomolgus monkey plasma.The method was qualified in the range 1.00-1000 μmol· L-1 and the lower limit of quantification set at 1.00 μmol· L-1.