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临床中对不稳定型心绞痛或AMI,需要快速、安全地抑制血小板聚集,否则,将会加重病情。阿司匹林具有抗血小板聚集及抗血栓形成的作用,理想的阿司匹林治疗必须是首次负荷量与小剂量维持的结合。本文研究了不同的负荷量与维持量对血小板功能的作用。从而找出一个能够达到抑制血小板功能的最佳负荷量与维持量。对象与方法选择64例健康男性进行双盲、安慰剂对照试验。将试验者随机分组,所有研究项目从上午8:00开始。第1d分别服用安慰剂或40、100、300、500mg阿司匹林做为负荷量。随后服用安慰剂或40、100mg/d阿司匹林维持。分别在服药前、后2、24h、第2、3、7和14d采血。观察(1)出血时间,
Clinical unstable angina or AMI, need fast and safe inhibition of platelet aggregation, otherwise, will aggravate the condition. Aspirin has anti-platelet aggregation and anti-thrombotic effects. The ideal aspirin treatment must be the combination of first-load and low-dose maintenance. This article studies the effect of different loadings and maintenance on platelet function. To find a can achieve the best load and maintenance of platelet inhibition function. Subjects and Methods Sixty-four healthy men were enrolled in a double-blind, placebo-controlled trial. Subjects were randomized and all research projects started at 8:00 am. Placebo or 40,100,300,500 mg aspirin were taken as loading on Day 1, respectively. Followed by placebo or 40,100 mg / d aspirin maintenance. Blood samples were taken before and after 2, 24, and 23, 7 and 14 days respectively. Observed (1) bleeding time,