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目的探讨腹腔镜下结直肠癌手术的低侵袭性。方法将符合纳入研究对象标准的40例结直肠癌患者随机分成腹腔镜组(20例)和开腹组(20例),比较两组患者围手术期(术前、术后当天、术后第1、3、5d)的外周血白介素(IL)-6、IL-8、肿瘤坏死因子(TNF)-α、C反应蛋白(CRP)、可溶性细胞间黏附分子(sICAM-1)、白细胞CD11b的变化。结果开腹组术后细胞因子(TNF-α、IL-6、IL-8)明显高于腹腔镜组(P<0.05)。开腹组术后6h、第1天时,sICAM-1的动态变化较腹腔镜组显著升高,开腹组外周血白细胞CD11b在术后6h降至最低(161.98±48.42),较腹腔镜组(189.51±46.45)明显低(P<0.05)。结论结直肠癌的腹腔镜手术比传统开腹手术对机体影响小,具有明显的低侵袭性。
Objective To investigate the low invasiveness of laparoscopic surgery for colorectal cancer. Methods Forty patients with colorectal cancer who were eligible for inclusion in the study were randomly divided into laparoscopic group (n = 20) and open group (n = 20). The patients underwent perioperative period (preoperative, postoperative, (IL-6), tumor necrosis factor (TNF) -α, C-reactive protein (CRP), soluble intercellular adhesion molecule (sICAM-1), leucocyte CD11b Variety. Results The levels of cytokines (TNF-α, IL-6 and IL-8) in the open group were significantly higher than those in the laparoscopic group (P <0.05). The dynamic changes of sICAM-1 in laparotomy group were significantly higher than those in laparoscopic group at 6h and 1d after operation. CD11b in laparotomy group was the lowest at 6h after operation (161.98 ± 48.42) 189.51 ± 46.45) was significantly lower (P <0.05). Conclusion Laparoscopic surgery of colorectal cancer has less effect on the body than traditional laparotomy and has obvious low invasiveness.