论文部分内容阅读
目的 目的探讨胰腺癌和慢性胰腺炎组织中白细胞介素8 (IL 8 )、单核细胞趋化蛋白1(MCP 1 )和巨噬细胞炎性蛋白1α(MIP 1α)的表达及其生物学意义,并探讨三者在胰腺癌中表达的相互关系。方法 采用ABC免疫组织化学法检测5 1例胰腺癌和1 0例慢性胰腺炎手术切除标本的上述各项指标。结果 胰腺癌IL 8,MCP 1和MIP 1α表达阳性率及其评分明显高于慢性胰腺炎(P< 0. 0 1 )。高分化腺癌的IL 8显著高于低分化腺癌(P < 0. 0 5 );未转移癌三者阳性率及评分明显低于伴转移病例(P< 0. 0 5或P < 0. 0 1 )。结论 IL 8,MCP 1,MIP 1α三者表达均为反映胰腺癌发生发展、生物学行为、转移发生及其预后的重要化学趋化因子;三者可能存在着相互影响和共同调控的作用途径。
Objective To investigate the expression of interleukin 8 (IL 8), monocyte chemotactic protein 1 (MCP 1) and macrophage inflammatory protein 1α (MIP 1α) in pancreatic cancer and chronic pancreatitis and its biological significance , And explore the relationship between the three expression in pancreatic cancer. Methods ABC immunohistochemistry was used to detect the above indexes in 51 cases of pancreatic cancer and 10 cases of chronic pancreatitis. Results The positive rates and the scores of IL 8, MCP 1 and MIP 1α in pancreatic cancer were significantly higher than those in chronic pancreatitis (P <0.01). IL 8 in well-differentiated adenocarcinoma was significantly higher than that in poorly differentiated adenocarcinoma (P <0.05); the positive rate and score of non-metastatic carcinoma were significantly lower than those with metastasis (P <0.05 or P <0. 0 1). Conclusion The expressions of IL-8, MCP-1 and MIP-1α are all important chemotactic factors that reflect the occurrence, development, biological behavior, metastasis and prognosis of pancreatic adenocarcinoma. The three pathways may interact and co-regulate.