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目的了解中国六省儿童HIV感染者的流行病学状况。方法对6个艾滋病高发省份的儿童感染者进行横断面调查,采集患者人口学、感染途径、诊断时间、临床分期、实验室检测等数据。结果共650例患儿入选,男405例,女245例,平均年龄(7.9±3.2)岁,可能感染到确诊的平均时间间隔为(7.1±3.2)年。依次分布于河南570例(87.7%),广西23例(3.5%),云南21例(3.2%),湖北19例(2.9%),安徽10例(1.5%),山西7例(1.1%)。其中母婴传播488例(75.1%),输血及血制品传播102例(15.7%),静脉吸毒传播3例(0.5%)。以采供血为主要传播途径的省份(包括河南、山西、湖北、安徽)和以静脉吸毒为主要传播途径的省份(包括广西、云南)感染者的平均年龄分别为(8.1±3.2)和(5.4±2.2)岁,两组相比差异有显著性(P<0.001)。178例(39.3%,178/453)符合接受抗病毒治疗标准,其中133例(74.7%,133/178)未接受治疗,45例(25.3%,45/178)采用成人药物治疗。结论母婴传播是儿童感染HIV的主要途径,应当加强我国儿童HIV感染者的诊断和治疗工作。
Objective To understand the epidemiological status of HIV-infected children in six provinces in China. Methods A cross-sectional survey of 6 HIV-infected children with HIV / AIDS in the province was conducted to collect demographic data, pathways of infection, diagnosis time, clinical stage and laboratory tests. Results A total of 650 children were enrolled. There were 405 males and 245 females, with an average age of (7.9 ± 3.2) years and an average time interval of 7.1 ± 3.2 years. Followed by Guangxi in 570 cases (87.7%), Guangxi in 23 cases (3.5%), Yunnan in 21 cases (3.2%), Hubei in 19 cases (2.9%), Anhui in 10 cases (1.5%) and Shanxi in 7 cases (1.1% . Among them, 488 cases (75.1%) were transmitted from mother to child, 102 cases (15.7%) were transfused with blood products and 3 cases (0.5%) were intravenous drug abuse. The average ages of infected provinces (including Henan, Shanxi, Hubei and Anhui) and provinces (including Guangxi and Yunnan) that use blood collection as the main route of transmission and intravenous drug use as the main routes of transmission were (8.1 ± 3.2) and (5.4 ± 2.2) years old, there was significant difference between the two groups (P <0.001). A total of 178 patients (39.3%, 178/453) were eligible for antiretroviral therapy. Of these, 133 (74.7%, 133/178) were untreated and 45 (25.3%, 45/178) received adult drug therapy. Conclusion The mother-to-child transmission is the main way of HIV infection in children and the diagnosis and treatment of children with HIV infection in our country should be strengthened.