Angew.Chem.Int.Ed.2017,56,10476~10480众所周知,金属催化Click反应得到的大都是五元环的三氮唑产物.福州大学化学学院翁志强课题组通过铜催化中断Click反应,第一次实现了六元环三氟甲基1,2,4-三嗪酮类化合物的合成.该反应是基于三氟乙酰基强吸电子性的特点,将其引入到Click反应中间体上,诱导该三氮唑中间体发生氮-氮键断裂而开环分解,形成活泼的烯酮亚 Angew.Chem.Int.Ed.2017,56,10476 ~ 10480 It is well known that the metal-catalyzed Click reaction mostly results in the five-membered ring triazole product. The Weng Zhiqiang group of Chemistry, Fuzhou University, through the Cu-catalyzed interrupting Click reaction, Times to achieve the synthesis of 6-membered trifluoromethyl 1,2,4-triazinones.This reaction was based on the strong electron-withdrawing property of trifluoroacetyl group and was introduced into Click reaction intermediates to induce The triazole intermediates nitrogen-nitrogen bond cleavage and open-ring decomposition, the formation of live ketene Asia