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目的 本实验观察大鼠肾上腺次全切除肾阳虚模型的胃、舌病理形态改变。方法 实验采用Wistar雄性大鼠,随机分为对照组和实验组。实验组行肾上腺次全切除术,对照做假手术。术后21d处死,主要观察胃、舌病理改变。结果 实验组见胃粘膜胃体腺腺颈部粘液细胞应激性增生,腺腔扩张,粘膜细胞胞浆空泡化及核固缩多见,胃小凹相对长度增加,胃体腺腺底相对厚度减少,胃体粘膜核分裂相频度减少而幽门粘膜核分裂相频度增加。无纤维组织增生和炎症性改变。实验组圆枕前后固有层乳头密度均增加,固有层乳头水肿。丝状乳头核空泡变明显。舌腺粘液腺酸性粘液增多。胃及舌肥大细胞密度和短径有增加或增加趋势。结论 肾上腺大部分切除肾阳虚证模型可见胃粘膜和舌粘膜、舌腺发生萎缩和退变,胃、舌的病理变化有相关性。而胃粘膜和舌腺的变化较舌粘膜更为敏感。
Objective To observe the pathological changes of the stomach and the tongue of rats with sub-total adrenalectomy and kidney-yang deficiency model. Methods Wistar male rats were randomly divided into control group and experimental group. The experimental group was subtotal adrenalectomy, control sham operation. 21d after operation, the main observation of gastric and tongue pathological changes. Results In the experimental group, gastric mucosal glandular adenocarcinoma mucosal cells stress hyperplasia, glandular cavity expansion, mucosal cytoplasmic vacuolization and nuclear pyknosis more common, relative increase in the relative size of the gastric fossa, glandular base of the gland relative Reduce the thickness, mucosal mitochondrial phase of gastric mucosa reduce the frequency of pyloric mucosal mitotic phase frequency increases. No fibrous tissue proliferation and inflammatory changes. Experimental group before and after the occipital pillow lamina propria density increased, lamina propria edema. Filiform papillary nuclei change significantly. The tongue gland mucus gland mucus increases. Stomach and tongue fat cell density and short diameter have an increase or increase trend. Conclusion Most of the adrenalectomy model of kidney-yang deficiency can be seen in the gastric mucosa and tongue mucosa, atrophy and degeneration of the tongue gland, gastric and tongue pathological changes are related. The gastric mucosa and tongue gland changes more sensitive than the tongue mucosa.