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混合性结缔组织病(MCTD)是一组病因不甚明瞭的胶原-血管性疾病,它包括风湿热(RF)类风湿性关节炎(RA)、系统性红斑狼疮(SLE)、皮肌炎(DM)、多发性肌炎(PM)、进行性硬化症(PSS)、结节性多动脉炎(PAN)、强直性脊椎炎(AS)及尿道-关节-结膜综合征等。由于病变累及多系统,故临床表现错综复杂且重叠交错,其病程大都呈亚急性或慢性经过。因此争取早期诊断,合理治疗,对减轻或防止脏器的损害、控制病情或预后转归等都有很大关系。我科近期内有两例儿童MCTD现报道如下:
Mixed connective tissue disease (MCTD) is a group of aetiological collagen-vascular diseases that include rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), dermatomyositis DM, PM, PSS, PAN, AS and urethral-conjunctival syndrome. Due to lesions involving multiple systems, so the clinical manifestations of complex and staggered overlap, most of the course was subacute or chronic after. Therefore strive for early diagnosis, reasonable treatment, to reduce or prevent organ damage, control of disease or prognosis prognosis and so have a great relationship. Two cases of MCTD in children recently reported in our department are as follows: