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前文曾报告对小白鼠脑内注射肾上腺素可协同吗啡的镇痛作用,并且对吗啡具有耐药性的小白鼠脑内注射肾上腺素亦表现了耐药性,由此启示吗啡与肾上腺素于中枢镇痛作用上可能存在有一定关系.已知吗啡能够释放中枢儿茶酚胺,因而有必要进一步探讨这种作用与镇痛的关系.另外也需要确定肾上腺素的镇痛作用是否有化学结构的要求,也就是这种作用是属于特殊性的或是一般非特殊性的抑制?只有属于前一类型,才有可能从受体概念上推论其镇痛作用.Leimdorfe在犬脑内给药所得到的资料,认为拟交感胺的镇痛作用与其苯环上的酚基具有密切关系,但是他没有精确比较它们之间的作用强度,而且所提麻黄碱等没有镇痛作用与文献报告亦有出入,因而有必要从剂量上进一
Previously reported on the mouse intracerebral injection of epinephrine may be synergistic morphine analgesic effect, and morphine-resistant mice intracerebral injection of epinephrine also showed drug resistance, suggesting that morphine and epinephrine in the central There may be a relationship between the analgesic effect of known morphine can release central catecholamines, it is necessary to further explore the relationship between this effect and analgesic.Also need to determine whether the epinephrine analgesic effect of chemical structure requirements, but also Is this a particular or general non-peculiar inhibition? It is only possible to infer the analgesic effect from the receptor concept, only if it belongs to the former type.Leimdorfe dosed the available data in the canine brain, It is believed that the analgesic effect of sympathomimetic is closely related to the phenolic groups on the phenyl ring. However, he did not accurately compare the intensity of action between them and the analgesic effects of ephedrine and the like were also different from those reported in the literature. Therefore, It is necessary to go from dose to volume