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目的探讨胃癌组织中KAI1和β-catenin在胃癌的发生、发展、浸润和转移中的作用。方法应用SP免疫组化技术,检测54例胃腺癌中KAI1和β-catenin的表达,并分析其与临床病理特征的关系和两基因之间的相关性。结果胃癌组织中KAI1低表达;β-catenin异常表达,且异常表达率与胃癌的淋巴转移、远隔转移、临床分期有关。多个因素的分组间差异有显著性(P<0.05),两者的表达呈负相关(r=-0.286,P<0.05)。结论胃癌组织中KAI1和β-catenin的表达与某些临床病理特征有关,且两种表达存在相关性。检测两者的表达水平对胃癌的诊断和预后可能有一定的参考价值。
Objective To investigate the role of KAI1 and β-catenin in the development, progression, invasion and metastasis of gastric cancer. Methods SP immunohistochemical technique was used to detect the expression of KAI1 and β-catenin in 54 cases of gastric adenocarcinoma. The relationship between the expression of KAI1 and β-catenin and the clinicopathological features and the correlation between the two genes were analyzed. Results The expression of KAI1 in gastric cancer tissues was low, and the abnormal expression of β-catenin was related to the lymphatic metastasis, distant metastasis, and clinical stage of gastric cancer. There was a significant difference between groups in multiple factors (P<0.05), and there was a negative correlation between the two groups (r=-0.286, P<0.05). Conclusion The expression of KAI1 and β-catenin in gastric cancer tissues is related to some clinicopathological features, and the two expressions are related. Detecting the expression levels of both may have certain reference value for the diagnosis and prognosis of gastric cancer.