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前列腺特异膜抗原(PSMA)是前列腺癌分子影像学研究的热点。但PSMA也可在非前列腺的生理组织及其他多种良恶性疾病中表达，特别是在肿瘤相关的新生血管内皮细胞中高表达。相关临床研究已表明PSMA配体PET显像在指导非前列腺癌的其他恶性肿瘤分期中具有应用价值。该文对PSMA配体PET显像在非前列腺肿瘤诊断和治疗中的应用进行综述。“,”Prostate specific membrane antigen (PSMA) is a hot topic in molecular imaging research of prostate cancer. However, non-prostate related PSMA can also be expressed in physiological tissues and different benign and malignant diseases, especially in tumor-associated endovascular endothelial cells. Related clinical studies have demonstrated the staging potential of PSMA ligands PET imaging in non-prostate tumors. This article summarizes the application of PSMA ligands PET imaging in the diagnosis and treatment of non-prostate tumors.