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研究了大鼠卵巢黄体中胰岛素样生长因子－Ⅰ受体（ＩＧＦ－ⅠＲ）与促黄体激素受 体（ＬＨＲ）的表达关系及调节．在动情周期中， ＬＨＲ阳性黄体能表达高水平的 ＩＧＦ－ ⅠＲ ｍＲＮＡ．动情期黄体的 ＬＨＲ表达水平降低，而 ＩＧＦ－ⅠＲ表达仍较高．假孕第 １天黄体中 ＬＨＲ表达较低，第８天达最高水平，第１４天表达已降低到检测不到的程度．与ＬＨＲ表 达不同，在第 １天假孕黄体中 ＩＧＦ－ⅠＲ的表达已较高，此后至第 １４天在黄体中均检测 到 ＩＧＦ－ ⅠＲ信号孕鼠黄体同时表达 ＬＨＲ和 ＩＧＦ－ ⅠＲ ｍＲＮＡ． ＩＧＦ－ Ⅰ刺激 ＬＨＲ ｍＲＮＡ 在黄体中的表达．前列腺素（ＰＧ）Ｆ２ａ抑制 ＩＧＦ－ ⅠＲ和ＬＨＲ的表达．ＰＧＥ２能消除ＰＧＦ２ａ对 ＩＧＦ－ＩＲ和 ＬＨＲ ｍＲＮＡ表达的抑制作用．上述结果提示：ＩＧＦ－Ｉ可能通过其受体的表达变化参与调节黄体功能、维持黄体结构．ＰＧＦ２ａ抑制 ＩＧＦ－ ＩＲ的表达可能是黄体萎缩 的机制之一．
The relationship and regulation of insulin-like growth factor-I receptor (IGF-IR) and luteinizing hormone receptor (LHR) expression in the rat luteal ovary were studied. During the estrous cycle, LHR-positive luteal can express high levels of IGF-IR mRNA. Luteal LHR LHR expression decreased, while IGF-IR expression is still high. The LHR expression in the corpus luteum was lower on the first day of pseudopregnancy and reached the highest level on the 8th day. The expression on the 14th day had been reduced to the undetectable level. Different from LHR expression, the expression of IGF-IR was higher on day 1 of pseudopregnant corpus luteum and LHR and IGF-IR mRNA were detected in the corpus luteum of all pregnant rats. The expression of LHR mRNA stimulated by IGF-Ⅰ in corpora lutea. Prostaglandin (PG) F2a inhibits the expression of IGF-IR and LHR. PGE2 abolished the inhibitory effect of PGF2a on IGF-IR and LHR mRNA expression. These results suggest that: IGF-I may be involved in the regulation of the function of the corpus luteum through its receptor expression changes, maintain corpus luteum structure. PGF2a inhibition of IGF-IR expression may be one of the mechanisms of luteal atrophy.