论文部分内容阅读
研究nm23-H1基因的表达与单结型肝癌的预后关系,组织切片应用免疫组化ABC法染色。59.4%为阳性染色,40.6%为阴性染色。两组肿瘤大小、包膜形成,侵及包膜、浆膜、肝内血管和胆管,肝内转移,细胞分化程度没有显著性差异。术后1年复发率阴性染色组(53.8%)明显高于阳性染色组(5.3%);3年以上生存率阳性染色组(63.2%)明显高于阴性染色组(23.1%)。结果表明:nm23—H1的基因表达,对单结节型肝癌的恶性程度和预后有指示作用
The relationship between the expression of nm23-H1 gene and the prognosis of uni-conjunctival hepatocellular carcinoma was studied. The tissue sections were stained with immunohistochemical ABC. 59.4% were positive staining and 40.6% were negative staining. There was no significant difference in tumor size, capsule formation, invasion of capsule, serosa, intrahepatic vessels and bile ducts, intrahepatic metastasis, and cell differentiation in both groups. The recurrence rate negative staining group (53.8%) was significantly higher than the positive staining group (5.3%) after one year; the positive staining group (63.2%) more than three years survival rate was significantly higher than the negative staining group (23 .1%). The results showed that the gene expression of nm23-H1 could indicate the malignancy and prognosis of single-nodular hepatocellular carcinoma.