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目的 通过对前白蛋白 (PA)的检测 ,了解其作为急性淋巴细胞白血病对肝浸润的意义。方法 对 2 2例治疗前患儿和完全缓解后的 1 7例患儿 ,通过免疫比浊法测定PA ,并检测其它肝功能指标 ,以及 30例健康儿童对照组。结果 2 2例治疗前患儿 ,9例PA下降 (与对照组相比P <0 .0 1 ) ,3例白蛋白降低 ,1例谷丙转氨酶、6例谷草转氨酶升高 ,1例总胆红素上升 ,治疗前PA异常的例数高于其它肝功能指标异常的例数。其中完全缓解后的 1 7例患儿 ,PA及其它肝功能指标则均在正常范围。结论 通过PA的检测 ,发现治疗前急性淋巴细胞白血病肝浸润时 ,PA的变化远较其它肝功能指标的变化为明显。
Objective To investigate the significance of prealbumin (PA) as a marker of hepatic infiltration in patients with acute lymphoblastic leukemia. Methods Twenty-two children with pre-treatment and 17 children with complete remission were enrolled in this study. PA was measured by immunoturbidimetry, and other liver function tests were performed. Thirty healthy children controls were also included. Results Among the 22 cases before treatment, 9 cases of PA decreased (P <0. 01 compared with the control group), 3 cases of albumin decreased, 1 case of alanine aminotransferase, 6 cases of aspartate aminotransferase increased, 1 case of total gall Red rose, PA abnormalities before treatment than other cases of abnormal liver function index number. Among them, 17 cases of complete remission, PA and other liver function indicators were in the normal range. Conclusions The changes of PA in the treatment of acute lymphoblastic leukemia with liver infiltration were found to be significantly more variable than those of other liver functions by PA test.