细胞因子主要是由免疫活性细胞产生的一系列免疫调节因子。近年研究发现,除免疫系统外,中枢神经系统(CNS)也能产生多种细胞因子,而且在CNS 中广泛存在IL-1,IL-2,IL-3和IL-6的结合位点。细胞因子对CNS 生理功能的影响及其在CNS 病理情况下的作用已成为神经生物学和免疫生物学非常活跃的研究热点。本文主要概述了IL-1,IL-2,IL-3和IL-6及其受体在CNS 中的分布以及这些因子在CNS 生理功能及病理变化中的作用。 Cytokines are primarily a series of immunomodulatory factors produced by immunocompetent cells. Recent studies have found that in addition to the immune system, the central nervous system (CNS) can produce a variety of cytokines, and IL-1, IL-2, IL-3 and IL-6 binding sites are widely present in the CNS. The effect of cytokines on the physiological function of CNS and its role in the pathological conditions of CNS has become a hot research topic in neurobiology and immunobiology. This article summarizes the distribution of IL-1, IL-2, IL-3 and IL-6 and their receptors in the CNS and the role of these factors in CNS physiological function and pathological changes.