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目的研究放射免疫分析测定胰岛素及C-肽在诊断2型糖尿病中的价值。方法选取2009年1月至2010年3月入湘潭县人民医院治疗的50例2型糖尿病患者组成病例组,应用放射免疫分析测定胰岛素和C-肽含量。选取2010年1月至2010年3月入湘潭县人民医院体检的健康人30例组成对照组,同样应用放射免疫分析测定胰岛素和C-肽含量,对比两组测定结果,以确定放射免疫分析测定胰岛素和C-肽在诊断2型糖尿病中的价值。结果相对于对照组,病例组患者空腹胰岛素及C-肽较高(P<0.05)。对照组患者在餐后1h后出现峰值,2型糖尿病患者餐后2h后出现峰值,持续到餐后3h后仍不能达到正常水平。结论运用放射免疫分析测定胰岛素及C-肽有助于为临床糖尿病分型及治疗提供指导。
Objective To study the value of radioimmunoassay in detecting insulin and C-peptide in the diagnosis of type 2 diabetes mellitus. Methods A total of 50 patients with type 2 diabetes mellitus who were admitted to Xiangtan People’s Hospital from January 2009 to March 2010 were enrolled in this study. The contents of insulin and C-peptide were determined by radioimmunoassay. 30 healthy people who were admitted to Xiangtan County People’s Hospital from January 2010 to March 2010 were selected as the control group, and the contents of insulin and C-peptide were also determined by radioimmunoassay. The results of two groups were compared to determine the radioimmunoassay The value of insulin and C-peptide in the diagnosis of type 2 diabetes. Results Compared with the control group, fasting insulin and C-peptide were higher in case group (P <0.05). Patients in the control group peaked at 1h postprandial and peaked at 2h postprandial in patients with type 2 diabetes, which did not reach normal levels 3h after meal. Conclusion The determination of insulin and C-peptide by radioimmunoassay can be helpful for the classification and treatment of clinical diabetes.