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急性心肌梗死(AMI)时的室性快速性心律失常用利多卡因单次静注50或100毫克的方法,有效血浆浓度(2微克/毫升)常常不能达到或很快(6分钟后)便下降。若静注100毫克后继以2毫克/分滴注速度维持,亦须迟至2小时后才能达到稳定的有效血浆浓度。为了维持单次注射后的有效血浆浓度和防止心律失常复发,在静注200毫克后,用2毫克/分滴注,虽可使血浆浓度一直保持在2微克/毫升以上,但开始的高浓度足以引起中毒。如增加滴注速度至4毫克/分,虽能很快上升至有效血浆浓度,但最终稳定的浓度已
Ventricular tachyarrhythmia at acute myocardial infarction (AMI) With a single intravenous 50 or 100 mg lidocaine, the effective plasma concentration (2 μg / ml) is often not achieved or quickly (after 6 minutes) decline. If the intravenous injection of 100 mg followed by 2 mg / min infusion speed, but also as late as 2 hours to achieve a stable and effective plasma concentrations. In order to maintain the effective plasma concentration after a single injection and to prevent the recurrence of arrhythmia, 2 mg / min infusion after intravenous injection of 200 mg, although the plasma concentration can be maintained at 2 micrograms / ml above, but the initial high concentration Sufficient to cause poisoning. If you increase the infusion rate to 4 mg / min, although can quickly rise to effective plasma concentration, but the final concentration has been stable