原发性胆囊癌由于缺少特有的临床表现，一经发现多属中晚期，疗效及预后极差。近年对其发病高危因素的研究越来越多的受到关注，且有一定进展，综述如下。１．胆石症与胆囊癌胆囊结石可以诱发癌变已被大多数外科学者所承认，全国第七届胆道外科会议资料表明６０％胆囊癌合并有 Because of the lack of specific clinical manifestations, primary gallbladder cancer has been found to be mostly in the middle and late stages, and its efficacy and prognosis are extremely poor. In recent years, more and more attention has been paid to the research on the risk factors of morbidity, and there has been some progress. The review is as follows. 1. Cholelithiasis and Gallbladder Carcinoma Gallbladder stones can induce cancerous changes. Most surgeons have recognized that the gallbladder cancer has been combined with 60% of gallbladder cancer.