论文部分内容阅读
已证实甲胎蛋白(AFP)在原发性肝癌和卵黄囊肿瘤时增高。本文报道1例原发性肺癌产生大量AFP,并利用AFP 与植物血凝素(LCH)的亲和力不同进行鉴别诊断。病例患者男75岁,因干咳、呼吸困难而入院。胸部X 线示右上肺5cm 大小的肿瘤阴影,伴有胸水和纵隔淋巴结肿大。肝脏CT 检查未发现肿瘤及肝硬化。胃内窥镜检、下消化道造影及头部CT 检查均未发现肿瘤。血清AFP 36 000ng/ml。病理学检查:经皮肺活检诊断为低分化型腺癌,AFP 用酶抗体法染色阳性,细胞体呈茶褐色。AFP 与LCH 的亲和力:采取植物血凝素交叉免疫电泳法,用刀豆素A(ConA)和LCH 作亲和力试验,其电泳图:ConA 呈现非结
Alpha-fetoprotein (AFP) has been confirmed to increase in primary liver cancer and yolk sac tumors. This article reported that 1 case of primary lung cancer produced a large amount of AFP, and the differential diagnosis was made using the affinity of AFP and phytohemagglutinin (LCH). The patient was 75 years old and admitted to hospital because of a dry cough and difficulty in breathing. The chest X-ray showed a tumor size of 5 cm in the upper right lung with pleural effusion and mediastinal lymphadenopathy. Liver CT examination revealed no tumors and cirrhosis. No tumors were found in the stomach endoscopy, lower gastrointestinal radiography, and head CT examination. Serum AFP 36 000 ng/ml. Pathological examination: Percutaneous lung biopsy was diagnosed as poorly differentiated adenocarcinoma. AFP was stained positive with enzyme antibody and the cell body was dark brown. Affinity of AFP and LCH: A phytohemagglutinin cross-immunoelectrophoresis method was used. Affinity tests were performed using ConA and LCH. The electrophoretogram of ConA showed non-knots.