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目的:探讨联合检测尿NGAL、KIM-1在判断重症患儿急性肾损伤(AKI)病情及预后中的作用。方法:以我院肾内科、PICU和健康体检儿童为观察对象,分为重症AKI组,重症非AKI组,CKD组和健康对照组,比较各组的血肌酐(sCr)和尿NGAL、尿KIM-1水平。结果:重症AKI组尿NGAL、KIM-1较重症非AKI组、CKD组、健康对照组明显升高(P<0.05),重症非AKI组、CKD组、健康对照组各组间差别无统计学意义(P>0.05)。尿KIM-1联合尿NGAL的峰值升高倍数和肾预后呈正相关,和CCr呈负相关关系。结论:尿NGAL和尿KIM-1水平与重症患儿AFI严重程度及肾预后有关。
Objective: To explore the role of combined detection of urinary NGAL and KIM-1 in judging the severity and prognosis of acute kidney injury (AKI) in critically ill children. Methods: The subjects were divided into seven groups: severe AKI group, severe non-AKI group, CKD group and healthy control group. The serum creatinine (sCr), urinary NGAL, urine KIM -1 level. Results: Urinary NGAL in severe AKI group, severe non-AKI in KIM-1 group, CKD group and healthy control group were significantly increased (P <0.05). There was no significant difference between severe non-AKI group, CKD group and healthy control group Significance (P> 0.05). The peak fold increase of urinary KIM-1 combined with urinary NGAL was positively correlated with renal prognosis and negatively correlated with CCr. Conclusions: The levels of urinary NGAL and urinary KIM-1 are related to the severity of AFI and the prognosis of the kidney in critically ill children.