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颗粒状石棉粉尘经气管注入大鼠肺内(分散度<5μm者占92%),以0.5、1、3、6、9月分期剖检。结果示染尘组大鼠的全肺干重及胶原蛋白含量均显著地高于同期正常对照组。病理形态改变以结节性病变及广泛的间质纤维化为其特点;肺门淋巴结见尘细胞灶聚集及网状内皮细胞增生。结论认为颗粒状石棉粉尘能致肺纤维化,提示时颗粒状或短纤维石棉的危害作用应引起高度重视。
Pelleted asbestos dust injected into the lungs of rats via trachea (dispersion <5μm accounted for 92%), 0.5, 1, 3, 6, 9 months staging. Results showed that the total lung dry weight and collagen content of the rats exposed to dust were significantly higher than the normal control group. Pathological changes to nodular lesions and extensive interstitial fibrosis as its characteristics; hilar lymph node tissue accumulation of dust cells and reticuloendothelial proliferation. The conclusion is that particulate asbestos dust can cause pulmonary fibrosis, suggesting that the harmful effects of granular or short asbestos should be given high priority.