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近十年来,用各种方法测定孕妇血清(或血浆)及羊水内甲胎蛋白(Alpha-fetoprotein,简称 AFP)的含量作为观察某些产科情况的指标,特别在对产前诊断开放性胎儿神经管缺陷(Neural tube defe-cts,简称 NTD_s)的研究工作,在国内外已广泛开展。关于妊娠时胎血内的甲胎蛋白进入羊水及母血循环的途径,虽有各种研究及推测,但还不完全清楚。AFP 是一种功能尚未完全确定的胚胎性物质(embryonic substance)属糖蛋白,人类 AFP的分子量为64,000～70,000 daltons,含糖量为3～4%。它有与雌激素结合的功能,亦有刺激生长及限制母体或胎儿抗体反应的免疫功能。有人报道鼠的 AFP
In the past ten years, the contents of alpha-fetoprotein (AFP) in pregnant women’s serum (or plasma) and amniotic fluid have been determined by various methods as indexes for observing some obstetric conditions, especially for prenatal diagnosis of open fetal nerve The research work of Neural tube defectes (NTD_s) has been widely carried out at home and abroad. Although there are various studies and speculations about the way of fetuin entering into amniotic fluid and maternal blood circulation during pregnancy, it is not yet completely understood. AFP is an embryonic substance whose function has not yet been completely determined. It is a glycoprotein that has a molecular weight of 64,000 to 70,000 daltons and a sugar content of 3 to 4%. It has the function of combining with estrogen, but also stimulates the growth and limits the immune function of maternal or fetal antibody reaction. Someone reported a mouse AFP