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目的探讨乏氧组织显像剂99Tcm-4,9-二氮-2,3,10,10-四甲基十二烷-2,11-二酮肟(HL91)SPECT/CT脑显像检测高血压脑出血出血灶周围乏氧组织的应用价值。方法22例高血压脑出血患者,和6例正常人均进行99Tcm-HL91SPECT脑显像,所有研究对象同时进行同机CT扫描。结果22例患者中18例阳性,阳性率为77.78%。4例阴性者分别是3例出血量<15ml的小量脑出血和1例出血量为23.5ml,起病43d行乏氧检查者。对照组6例均为阴性。乏氧区位于出血区周围,少量出现在血肿内,乏氧体积大小与出血量有正相关关系。结论99Tcm-HL91SPECT显像可较好地显示高血压脑出血病病灶周围的乏氧组织,乏氧体积与出血量有密切关系,可应用于指导临床治疗。
Objective To investigate the detection of 99Tcm-4,9-diaza-2,3,10,10-tetramethyldodecane-2,11-dione oxime (HL91) SPECT / The value of hypoxic tissue around hemorrhagic foci of intracerebral hemorrhage. Methods Totally 99 Tcm-HL91 SPECT brain imaging was performed in 22 patients with hypertensive intracerebral hemorrhage and 6 normal controls. All subjects underwent CT scan simultaneously. Results Of the 22 patients, 18 were positive and the positive rate was 77.78%. 4 cases of negative were 3 cases of bleeding <15ml small amount of intracerebral hemorrhage and 1 case of bleeding was 23.5ml, 43d onset hypoxia were. The control group of 6 patients were negative. Hypoxia area is located around the hemorrhage area, a small amount in the hematoma, hypoxia volume and the amount of bleeding has a positive correlation. Conclusion 99Tcm-HL91 SPECT imaging can better display the hypoxic tissue around hypertensive intracerebral hemorrhage lesions. The hypoxic volume is closely related to the amount of bleeding and can be used to guide the clinical treatment.