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目的探讨肛提肌中结蛋白和波形蛋白的表达与女性盆底组织膨出(POP)发病的关系。方法选择2004-12-2006-01就诊于南京军区福州总医院的20例POP患者为研究组,20例无POP和压力性尿失禁的直肠癌患者为对照组,术中取肛提肌活组织检查,采用免疫组织化学和电子显微镜技术观察肌细胞内结蛋白和波形蛋白的表达。结果POP患者中结蛋白和波形蛋白的含量均较对照组少,差异均有统计学意义(P<0.05)。结论盆底肌肉结蛋白和波形蛋白表达的减少,从形态学上说明其为导致POP发生的重要因素之一。
Objective To investigate the relationship between the expression of desmin and vimentin in levator ani and the incidence of pelvic floor swelling (POP) in females. Methods Twenty patients with POP in Fuzhou General Hospital of Nanjing Military Command from December 2004 to June 2006 were selected as study group. Twenty patients with rectal cancer without POP and stress incontinence were selected as control group. Inspection, using immunohistochemistry and electron microscopy to observe the intracellular desmin and vimentin expression. Results The levels of desmin and vimentin in POP patients were lower than those in control group, with significant differences (P <0.05). Conclusions The reduction of pelvic floor protein and vimentin expression is one of the important factors that cause POP occurrence.