类风湿关节炎(RA)是多种因素作用,通过T细胞激活的自身免疫过程,从而导致关节渐进性损害的慢性疾患。其病理生理机制不清楚,但在家族中,RA与其它自身免疫性疾病如甲状腺疾病、胰岛素依赖型糖尿病(IDDM)相关联。通过家族聚发性法(λ_s=5,指RA同胞患者与普通人群发病率之比)、双生子法以及分离法等分析,发现RA与遗传因素有关。 Rheumatoid arthritis (RA) is a multifactorial, chronic disease that causes progressive damage to joints through the autoimmune process of T-cell activation. Its pathophysiological mechanism is unclear, but in the family RA is associated with other autoimmune diseases such as thyroid disease and insulin-dependent diabetes mellitus (IDDM). Through family clustering (λ_s = 5, the ratio of RA siblings to the general population), twins and sub-methods, we found that RA was related to genetic factors.