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[目的]控讨C－erbB－2基因产物表达在胃癌的进展、生物学行为及预后判断中的作用。[方法]应用免疫组织化学方法研究C－erbB－2在63例胃癌标本中的表达。[结果]C－erbB－2原癌基因产物在进展期胃癌组、伴有淋巴结转移组及体有血管或神经侵犯组的阳性表达率分别为64．9％，74．2巩和66．7％。C－erbB－2表达与胃癌的分级和分化程度，淋巴结转移等有关（P＜0．05）。[结论]C－erbB－2原癌基因检测可作为胃癌生物学行为和胃癌预后判断的重要指标。
[Objective] To investigate the role of C-erbB-2 gene product expression in the progression, biological behavior and prognosis of gastric cancer. [Methods] The expression of C-erbB-2 in 63 specimens of gastric cancer was studied by immunohistochemistry. [Results] The positive expression rates of C-erbB-2 proto-oncogene products in advanced gastric cancer group, lymph node metastasis group and vascular or nerve invasion group were 64.9%, 74.2 Gonghe and 66.7 respectively. %. The expression of C-erbB-2 was related to the grade and differentiation of gastric cancer and lymph node metastasis (P<0.05). [Conclusion] The detection of C-erbB-2 proto-oncogene can be used as an important indicator of gastric cancer biological behavior and prognosis of gastric cancer.