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丹参为常用中药,其药理作用已有许多报道.本文首次报道从丹参提取的7种成分:丹酚酸A,丹酚酸B,原儿茶醛,丹参素,咖啡酸及迷迭香宁酸对生物膜过氧化损伤的保护作用.上述化合物的结构式均经多种光谱确证,系纯品,溶于水. 结果表明,上述7种化合物10μg能显著抑制铁离子/半胱氯酸和维生素C/NADPH所引起的肝脏微粒体脂质过氧化,丙二醛生成量明显减少,对H_2O_2引起的大鼠红细胞溶血和脂质过氧化亦有显著抑制效用.其中以丹酚酸A的活性最强,抑制率达90％以上.其次为丹酚酸B>原儿茶醛>原儿茶酸>丹参素>咖啡酸>迷迭宁
Salvia miltiorrhiza is commonly used traditional Chinese medicine, and its pharmacological effects have been reported.In this paper, the first seven components extracted from Salvia: salvianolic acid A, salvianolic acid B, protocatechuic aldehyde, danshensu, caffeic acid and rosemary acid On the protective effect of biofilm peroxidation.Compounds of the above compounds are confirmed by a variety of spectroscopy, the Department of pure, soluble in water.The results show that the above 10 compounds 10μg can significantly inhibit the iron / cysteine and vitamin C / NADPH induced liver microsomal lipid peroxidation, malondialdehyde production was significantly reduced, H_2O_2-induced rat erythrocyte hemolysis and lipid peroxidation also had significant inhibitory effect of which salvianolic acid A the strongest activity , Followed by the inhibition rate of more than 90%, followed by salvianolic acid B> protocatechuic aldehyde> protocatechuic acid> danshensu> caffeic acid> verapamil